I. verb — [with obj.] 1. cause (someone) to become hostile • the aim was to antagonize visiting supporters.
[Biochemistry] (of a substance) act as an antagonist of (a substance or its action).
• two other drugs antagonized the antidepressant-like effect.
– origin mid 18th cent. (in the sense ‘struggle against’): from Greek antagōnizesthai, from ant- ‘against’ + agōnizesthai ‘struggle’ (from agōn ‘contest’).